How Levitra (Vardenafil) Works?
Levitra (vardenafil), a phosphodiesterase-5 enzyme inhibitor (PDE-5), means it blocks PDE-5. This reduces blood flow to the penis and relaxes muscles. Read complete blog to know:- How Levitra Works?
What Does Levitra (Vardenafil), Serve?
- Erectile Dysfunction
- Levitra (Vardenafil) Dosage Forms
- 2.5mg, 5mg, 10mg, 20mg
Typical Dosing for Levitra (Vardenafil)
Levitra (vardenafil), is usually taken in 10 mg increments 1 hour prior to sex. Depending on its effect, the dose can be adjusted from 5 to 20 mg. Order online Levitra (vardenafil), should not be taken more often than once daily.
- A first-choice medication for treating erectile dysfunction
- It works slightly faster than Viagra (sildenafil), Cialis (tadalafil), but lasts slightly longer than Viagra
- Dissolving tablets (brand name Staxyn) are available. These can be used to speed up the process of swallowing pills.
- It should be taken approximately 1 hour before having sex.
- If you have had a stroke or heart attack in the last 6 months, this cannot be taken.
- You can’t use if you have recently taken nitrates such as Imdur, Isordil or Nitroglycerin (NitroBID, Nitro-Dur and Nitrostat).
- People 65 and older could have more side effects. Take this medication with care
- Tips for pharmacists regarding Levitra (vardenafil).
- Levitra (vardenafil), works best when taken between 30 and 60 minutes prior to sexual activity.
- Levitra (vardenafil), works faster when it is taken empty stomach.
- Vardenafil (levitro) is not able to stop the spread sexually transmitted diseases (STDs), like HIV and herpes. Safe sex is important.
- Staxyn, another tablet form of Vardenafil, dissolves on the tongue immediately and can be taken without liquid. It is important to not take the tablet out of its packaging until you are ready to use it.
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What Side Effects Can Levitra (Vardenafil), Cause?
There are both risks and benefits to any medication. You may experience unwanted side effects even if your medication is effective. Any of these symptoms, contact your doctor.For more than four hours, erection can be expected
- Vision Loss
- Hearing Loss
These side effects can improve over time as your body adjusts to the medication.
Common side effects
- Headache (15%)
- Flushing (11%)
- Nasal congestion (9%)
- Indigestion (4%)
- Symptoms of cold/flu (3%)
- Dizziness (2%)
- Nausea (2%)
- Pain in the back (2%)
What are the warnings and risks associated with Levitra (vardenafil).
Some serious health problems can be caused by Levitra (vardenafil). For certain groups, the risk could be higher. Talk to your pharmacist if you are concerned about this.
Risk if Hearting Attack or Stroke
Risk Factors: Recent Heart Attack or Stroke in Past 6 Months
Men should not take Order online Levitra (vardenafil), if they have had a stroke, heart attack, or other symptoms of heart disease in the last 6 months. These situations have not been considered safe for Levitra (vardenafil). If you have any of the above conditions, talk to your doctor.
QT PROLONGATION (ABNORMAL HEAR RHYTHM).
Risk factors: You are currently taking any other medication that may prolong your QT.
Vardenafil (levitar) has been shown in studies to increase the QT interval and cause irregular heart beats. Your doctor should know if you’re taking any other medications. There may be safer options.
LOW BLOOD PRISE
Risk factors: Taking medications for high blood pressure or chest pain (angina)
Your blood pressure could drop too low if you are taking alpha-blockers or medication for high blood pressure with Levitra. If you take these medications, make sure to monitor your blood pressure. You should be careful when you get up from a sitting, lying down or standing position.
This can cause dizziness and increase your chances of falling. Low blood pressure can also be caused by alcohol consumption. Levitra (vardenafil) can cause low blood pressure if you don’t drink enough alcohol. Avoid taking Order online Levitra (vardenafil), while you are taking nitrate medication to treat chest pain (angina). It can cause blood pressure to drop suddenly, which could lead to serious complications.
Risk factors: Cavernosal Fibrosis
Men have reported experiencing an extended erection with Levitra (vardenafil). Although it is uncommon, if this happens, permanent damage to your penis can occur, including impotence.
If you notice sudden changes in vision in one or both of your eyes, call 911 immediately. Even though it is uncommon, permanent eye damage can be caused by Levitra (vardenafil).
Some men have experienced permanent hearing loss after taking Levitra (vardenafil). It could also cause ringing in your ears (tinnitus), dizziness, and ringing in your ears. If you notice any changes in your hearing in one of your ears, or both, call your doctor or go to the emergency department immediately.
INCREASED SIDE EFFECTS AFTER OTHER MEDICINES
Risk Factors: Liver Disease
Side effects may be more severe if you take Order online Levitra (vardenafil), certain medications that cause chest pain, blood pressure medication, and other medications. If any of these are applicable to you, talk to your doctor before taking Levitra (vardenafil).
Use of LEVITRA or nitrates simultaneously Nitric oxide Donors are not permitted. Blood pressure-lowering effects of sublingual Taken 1 and 4 hours after Vardenafil, nitrates (0.4mg) and an increase in heart rate taken 1, 4, and 8 hours later were potentiated with a 20 mg dosage of LEVITRA in healthy middle age subjects. These effects did not occur when LEVITRA 20mg was taken 24 hours prior to the nitroglycerin (NTG). Potentiation Hypotensive Effects of nitrates on patients with ischemic heart disease Heart disease It has not been evaluated and the concomitant administration of LEVITRA or nitrates are contraindicated.
When PDE5 inhibitors and alpha-blockers are administered together, it is important to be cautious. Vasodilators with blood-pressure-lowering effects. Combinations of vasodilators may result in an additive effect on blood pressure. Clinical Pharmacology Studies have been done with vardenafil and alfuzosin co-administration.
This was in comparison to placebo. It also led to a maximum increase of 4 beats per hour. The maximum blood pressure drop occurred between 1 to 4 hours after the dose. Similar blood pressure responses to multiple doses over 31 days were seen on Day 31 and Day 1.
When administered with alcohol (0.5g/kg bodyweight, or approximately 40mL for a 70kg person), LEVITRA (20mg) did not cause hypotension in healthy volunteers. Dosing with vardenafil simultaneously did not alter the plasma levels of alcohol and vardenafil.
Clinical Studies Experience
Over 4430 men received Order online Levitra (mean age 56; range 18-89 year old; 81% Black, 6% Black and 2% Asian and 9% other) in controlled and uncontrolled clinical trials around the world. More than 2200 patients were treated over 6 months and 880 were treated for at most 1 year.
The discontinuation rate for adverse events in placebo-controlled clinical trials was 3.4% for LEVITRA, compared to 1.1% with placebo.
Placebo-controlled studies showed that there was a dose effect on the incidence of certain adverse reactions (headache and flushing), over the LEVITRA doses of 5 mg, 10mg, and 20mg.
All Vardenafil Studies
Over 17,000 men have received LEVITRA orally disintegrating tablets and LEVITRA film-coated tablets. These tablets were administered in controlled and uncontrolled clinical studies worldwide.
The discontinuation rate for adverse events in the placebo-controlled clinical trials of LEVITRA film-coated tablets versus vardenafil orally-dissolving tablets was 1.9% for Vardenafil, compared to 0.8% in the placebo.
Below is a list of additional, less common adverse reactions (2%), that were reported during clinical development of LEVITRA films-coated tablets and Vardenafil orally disintegrating tablet. This list excludes adverse reactions that are rare and minor, events that can be observed even without drug therapy and events that cannot reasonably be attributed to the drug.
Dosage Forms and Strengths
LEVITRA is an orange-colored, film-coated tablet containing “BAYER”, cross debossed one side and “2.5”, 5″, “10”, and “20” the other.
Storage and Handling
LEVITRA (vardenafil HCl)It is made up of orange-colored, film-coated, round tablets coated with a cross containing “BAYER”, “2.5”, “5” and “10” respectively. This gives you the equivalent of 2.5 mg, 5mg, 10mg, and 20mg of Vardenafil.
Guanylate Cyclase GC (GC) Stimulators such as riociguat – Concomitant use of this stimulator is not recommended
Inhibitors of CYP3A4
Patients who are taking potent CYP3A4 inhibitors, such as Order online Levitra, may need to adjust the dosage. ketoconazoleItraconazole. Ritonavir. Indinavir. Saquinavir. Atazanavir. ClarithromycinAs well as other patients who are receiving moderate CYP3A4 inhibitions, such as Erythromycin. A single dose of 2.5mg LEVITRA should be used for ritonavir. This should not exceed 72 hours. Indinavir and saquinavir should be used together. A single dose of 5mg LEVITRA is recommended for ketoconazole 200mg daily, itraconazole 20mg daily, and erythromycin.
If the patient is on stable alpha-blocker therapy, concomitant treatment should only be initiated if the patient is not. Patients who are taking vardenafil or a phosphodiesterase (5 (PDE5) inhibitor may experience a stepwise increase in their alpha-blocker dosage. This could cause further blood pressure drops.